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About Impmk2

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  1. NZ (& Aus) are inoculating around 1.5% of the population per day. Both getting towards 60% on first shots. Set to overtake the US and be on par with much of Europe towards the end of October. Like much of the rest of Asia we didn't really get much vaccine here until a couple months ago. Here in Australia we only just opened eligibility to below 40s at the start of this month.
  2. I'm glad that's the view from the French side. I think that's overwhelmingly the view here on the Australian side too. I'd previously heard no mention of any strategic partnership, and I tend to follow the news pretty closely. Think most people here will view it as a calculated overreaction and hard to take seriously. The US deal is being sold as far more about the US taking a more active role in the pacific.
  3. I played waaay too much when I was an undergrad back in 2004-2006. Ended up main tanking an end game guild through to Naxx. All fell apart in TBC with the shift from 40 mans, and guild drama around the A and B teams. I played a few more expansions with some friends after that. Always levelling to the new max level and running through the first few raids. Had close to 365 days /played last time I logged on to that warrior. Still keep in touch with some of the friends I made back those days.
  4. You really do get used to 2-3hr training runs at an easy pace. They're a very necessary part of marathon training. Used to be able to run an easy 25-30k on Saturday and still be good for an interval session on Tuesday and mid-week 10k each way to and from work on Wednesday. 3hrs+ you start getting a high potential for injury though. 1.5hrs+ at pace is a completely different story. I could never train properly for a couple weeks after racing a half. All this running talk makes me want to put the weights down and get back out on the road.
  5. I'm surprised it isn't much lower than those. I've seen several publications mention the lower mutation rate making it a good vaccine candidate when compared to other RNA viruses. I at least don't think influenza is a great comparison for it in any case - has the propensity for antigenic shift due to the segmented nature of its genome.
  6. The coronavirus RdRP which is shared by sars-cov-2 has a somewhat uniquely high fidelity in the RNA virus world. It has a proof reading mechanism. Far lower mutation rate than most RNA viruses.
  7. Somewhat random thoughts on the booster conversation: 1) The variants which have really taken off so far (D614G, alpha, delta) seem to have had a fitness advantage largely brought about by increased transmissibility rather than immune evasion. Ie the virus is evolving to become more human adapted. 2) The major antigen (spike) can only mutate towards increased ACE2 affinity so far - it cannot infinitely evolve towards increased transmissibility and will get to a point of increasingly diminishing returns. When it gets towads that point (if we're not already there, which my gut says we might be*) further mutations will likely be towards immune evasion & reinfection. These may be less (not more) transmissible. 3) Almost all of the variants so far share a half dozen or more of the same substitutions. That includes the potential escape mutants. 4) This virus is not evolving particularly quickly. A dozen or so amino acid substitutions in billions of generations isn't a high rate of mutation for a virus. So with all of this in mind it seems insane not to tailor booster shots to Delta like, yesterday. *I also thought this last year. That turned out well.
  8. Wouldn't stress too much over a couple miles at this stage. Better to get to the start line as healthy as you can. Race day adrenalin and determination will get you to the finish line on the day.
  9. Goodluck! Take it very easy. 3:15 is super long for a training run.
  10. Yeah almost every expert I've seen talk about it seems to think they're lowballing there and should hold out for 80% like Vic seems to be planning. The one thing that makes me think it may work is that NSW is well on target to end up at over 85% of over 16s double vaxxed, and possibly over 90% in much of Sydney. They've hit 75% single dose this week with a pretty minimal slowdown, and still dosing at a solid 0.7% first doses a day. So while they'll "only" be at 70% 16+ double vaxxed it'll be a pretty short window before it hits 80%+, with the vast majority of the rest of the 16+ population on 1 dose which is still significantly protective in itself. And that's not including that we're going to start jabbing the 12+ population quite soon. In any case this is quite a bold move, which could kill a lot of people and cost Berejiklian her job if it backfires.
  11. My question is why release a trailer in 2021 only in 1080p? Random vblogs are in 4k these days...
  12. I thought they were intentionally avoiding any UK style freedom day branding to avoid people trying to revert to pre-covid behaviour of a sudden. But I guess media is going to media. Random new case just popped up in a school in QLD....
  13. For covid specific monoclonals yes, though I imagine they'd use a soluble portion of the spike protein receptor binding domain rather than full length. Oh that's another difference - you're literally only getting lots of a single antibody. During vaccination your body produces different antibodies to many of the bits (epitopes) of the spike. It's a big protein. So if the monoclonal doesn't bind well due to there being a mutation there (varient) you're out of luck. ETA: if you had a variety of antibodies it'd be a polyclonal. They don't use those for therapies afaik, too much variability.
  14. Yeah that would be a lovely way, the reality is somewhat less pleasant. Monoclonal antibodies are created by injecting a mouse (or other small mammal) with the antigen, waiting for an immune response, killing the animal and harvesting the spleen, then fusing the b-cells with myloma cells to immortalise them. But the rest is broadly correct, though you're only focusing on the circulating antibody side of the immune response. Theres a variety of different subtypes of antibodies and you'll only be getting 1. Not to mention t-cell driven immunity (nk cells etc).
  15. God these Craig Kelly UAP ads are the worst. Couldn't Clive even find a catchy song to plagiarise this time? I guess he's got plenty more money to flush down the toilet
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